Working in collaboration with Dr. Colleen Doherty’s lab at North Carolina State University, Mimetics researchers have shown for the first time that warm nighttime temperatures disturb the circadian patterns of gene expression in rice plants, leading to depressed yields. This effort involved a careful study of time series transcriptional data from the entire rice genome. The work required an analysis of the ways in which these patterns were altered when the plants were exposed to warmer than average nighttime temperatures that relied on Mimetics’ advanced analytics. Developing and growing rice plants that provide high yields in spite of warmer nights is crucial as global climate change continues. The results are described in a paper that can be found at https://www.biorxiv.org/content/10.1101/702183v1.
At the N.C. Biotechnology Center Professional Forum on May 1, 2019, Mimetics presented its work with Dr. Colleen Doherty of N.C. State University on the “Effects of Warm Night Time Temperatures due to Climate Change on the Circadian Gene Expression Patterns of Rice Plants.”
Mimetics is working with Dr. William Kraus and his group at the Duke Molecular Physiology Institute to develop new assays for characterizing human circadian patterns.
Mimetics is pleased to announce that Dr. Jacob Pritt is joining our team as a computational scientist. Jacob comes to Mimetics after earning his PhD in Computer Science from Johns Hopkins. Jacob’s research has focused on improving the scalability and accuracy of sequencing analysis tools in the context of increasingly large experiments.
Mimetics is working with Dr. Ralph Dean, an expert on fungal diseases in crop plants, to identify early transcriptional responses to fungal infection.
Mimetics is pleased to announce that Precision fermentation, Inc. (“PFI”), a company that Mimetics has incubated to develop a system for monitoring beer fermentations, is now an independent entity with its own funding and management. Mimetics wishes the new company well and looks forward to great things from PFI.
Mimetics is working with Dr. Colleen Doherty, an expert on abiotic stress on a project to study the effects of heat stress due to climate change on rice plants and their productivity.
Mimetics has combined its laboratory and corporate offices and moved to Research Triangle Park. We are now in the old Hamner Building on Davis Drive.
Mimetics is pleased to announce that it has been awarded a Phase I SBIR grant from the National Science Foundation (NSF). This award, which falls under the Computational Biology and Bioinformatics funding program, will assist us in two major ways. First it will help in the development of our newest software and algorithms that assist in analyzing gene expression data. Secondly,the SBIR will enhance our work into gene regulatory networks as well as a greater understanding of these critical networks that underlie so many biological processes.
Dr. Ashlee Valente is our newest hire at Mimetics. Dr. Valente earned her B.S. and M.S. in Bioinformatics at Rochester Institute in Technology and completed her doctoral studies at Duke University in Computational Biology and Bioinformatics. Ashlee’s doctoral thesis work focused on the development of statistical models to improve computational pre-processing of transcriptomics and proteomics data. During her postdoctoral work, Ashlee worked extensively on applied biomarker discovery. She has extensive experience building predictive models for clinical outcomes in infectious disease and biopolymer exposure in transcriptomics, proteomics, and metabolomics data. Dr. Valente brings with her an enthusiastic pursuit of leveraging this type of data via quantitative systems biology to advance understanding of biological mechanisms.
- Mimetics’ analytics help to show that loss of yield in rice plants from warm nighttime temperatures results from changes induced in plant circadian patterns July 18, 2019
- Mimetics Presents at the N.C. Biotechnology Center May 9, 2019
- Mimetics is Teaming with Dr. William Kraus and the Duke Molecular Physiology Institute February 10, 2019
- Dr. Jacob Pritt Joins Mimetics January 7, 2019
- Mimetics is Collaborating with Dr. Ralph Dean and his Lab at N.C. State March 3, 2018
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Durham, NC 27709