How is Mimetics Helping Companies and Researchers Solve Problems?
Fermentation and other biologically driven production processes are used throughout the Life Sciences. Sophisticated systems for collecting chemical and physical data such as cell count, temperature, pH, DO2 and other parameters are typically used to monitor them. More recently, genetic information on the micro-organisms has become widely available. But even with all this data, up to now it has not been possible to uncover what is happening within the micro-organisms as these biological processes take place.
Mimetics’ technology opens up a window on molecular processes within the micro-organisms in commercial production systems that can intrigue even experienced fermentation scientists and engineers. Mimetics technology enables the identification of key transcriptional regulators of cell level processes such as proliferation, stress response and metabolite production. Such information can substantially speed up the development of new micro-organism strains, enable the development of new products and improve the efficiency of existing production processes
Interested in Fermentations for Beer and Wine? Go to Precision Fermentation for information on the BrewMonitor System, the first real-time comprehensive fermentation monitoring system designed for breweries!
The AgBio industry is engaged in a continuing quest for increased productivity from the plants and animals that growers raise. From limited and environmentally sensitive resources of land, water and energy, agriculture around the world is called upon to feed an ever-growing population. Rapid advances in genomics have been useful, but reaction to GMO’s has limited their value. AgBio companies also find that there can be enormous hurdles in bringing advances from the lab and greenhouse out into the field and the underlying causes of these problems often remain mysterious. A new generation of AgBio research has begun to focus on microbiomes both outside of and inside of the animal or plant of interest and the result has been the compilation of enormous data collections that await analysis.
Mimetics computational platform works to analyze how genetic patterns are expressed in phenotypes and the dynamics of the regulatory networks that govern this expression. Two genetically ‘identical’ organisms may respond in very different ways to environmental stresses depending on the circumstances under which those stresses are applied (time of day for example). The same is true for signaling pathways between cells which permit organisms to communicate in a microbiome. These analyses require large amounts of data to be collected according to demanding protocols and then analyzed to extract the dynamics. Mimetics technology is built precisely to handle these challenges.
• Mimetics- AgBio (PDF)
Human Health & Pharmaceuticals
Researchers looking for new drugs are accustomed to identifying ‘targets’ within the molecular pathways that characterize diseased cells. If such targets can be disabled the pathway can be shut down with positive consequences for the health of the cell. Very many new pharmacological interventions have been discovered in just this way. But researchers are often frustrated to find that the disabling of one target can give rise to compensating mechanisms within the cell that permit the pathway to continue to function
Mimetics’ tools can help researchers obtain a more comprehensive picture of the networks that are connected to the targets they are interested in. They can then see how compensating mechanisms or other processes may become unintended consequences of the application of the drug to the target. This can help refine and improve the drug discovery process.
Mimetics is also applying its technology to the problem of identifying new therapies and our research into fungal cell cycles has led us to a new approach to anti-fungal and fungicidal agents. Mimetics continues to do basic research in this area and welcomes opportunities to work with organizations that have drug development expertise and are interested in novel anti-fungal treatments.
- Mimetics White Papers November 20, 2020
- Mimetics’ analytics help to show that loss of yield in rice plants from warm nighttime temperatures results from changes induced in plant circadian patterns July 18, 2019
- Mimetics Presents at the N.C. Biotechnology Center May 9, 2019
- Mimetics is Teaming with Dr. William Kraus and the Duke Molecular Physiology Institute February 10, 2019
- Dr. Jacob Pritt Joins Mimetics January 7, 2019
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